| 发明名称 |
LIPOSOME COMPOSITION AND METHOD FOR PRODUCING SAME |
| 摘要 |
Provided are a liposome composition in which an osmotic pressure of an inner water phase is 2-fold to 8-fold relative to the osmotic pressure of an outer water phase, and which encapsulates a water-soluble drug in a dissolved state, and also exhibits excellent preservation stability; and a method for producing the same. According to the present invention, it is possible to provide a liposome composition, including liposomes obtained from lipids dissolved and emulsified in an organic solvent, each of which has an inner water phase and an aqueous solution which constitutes an outer water phase and in which the liposomes are dispersed, in which each of the liposomes encapsulates a water-soluble drug in a dissolved state, and an osmotic pressure of the inner water phase is 2-fold to 8-fold relative to the osmotic pressure of the outer water phase; and a method for producing the same. |
| 申请公布号 |
US2017042813(A1) |
申请公布日期 |
2017.02.16 |
| 申请号 |
US201615336158 |
申请日期 |
2016.10.27 |
| 申请人 |
FUJIFILM Corporation |
发明人 |
ONO Makoto;ONO Kohei;MATSUMOTO Takeshi;MORI Mikinaga |
| 分类号 |
A61K9/127;A61K31/7068 |
主分类号 |
A61K9/127 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A liposome composition, comprising:
liposomes obtained from lipids dissolved and emulsified in an organic solvent, each of which has an inner water phase and an aqueous solution which constitutes an outer water phase and in which the liposomes are dispersed, wherein each of the liposomes encapsulates a water-soluble drug in a dissolved state, and an osmotic pressure of the inner water phase is 2-fold to 8-fold relative to the osmotic pressure of the outer water phase. |
| 地址 |
Tokyo JP |
