| 摘要 |
Provided herein are nucleic acids, recombinant adeno-associated virus (rAAV) particles, and compositions, as well as methods of use thereof for inducing immune responses, including protective immune responses for preventing or treating cancer. In some aspects, the rAAV particle includes a nucleic acid that expresses a cancer associated antigen. In some aspects, the rAAV particle is a rAAV particle having a mutation in a surface-exposed amino acid, such as tyrosine, threonine, or serine, that enhances transduction of dendritic cells. |
