| 摘要 |
Catalin drug intermediates 1,2,4-trihydroxybenzene triacetate synthesis method, comprising the following steps: equipped with a stirrer, a thermometer, a reaction vessel was added 2.9-3. 1mol 4'-methyl-acetanilide, a certain concentration of 200ml phosphoric acid solution, stirring speed was controlled at 200-260rpm, 0.9mol p-benzoquinone was added in batches, the temperature of the solution is controlled at 60--65 C, the temperature of the solution was dropping naturally during the agitation, there exists solid precipitation after cooling, the temperature of the solution is reduced to 15--19 C, 2L a certain concentration of potassium chloride solution was added, white crystals precipitated, the temperature of the solution was reduce to 11--13 C, filtered, the product was recrystallized from acetone solution with the mass fraction of 90%, and dried in vacuum, ultimately got white granular crystalline 1,2,4-triacetoxy benzene. |
