| 发明名称 |
FC-REGION VARIANTS WITH IMPROVED PROTEIN A-BINDING |
| 摘要 |
Herein is reported a polypeptide comprising a first polypeptide and a second polypeptide each comprising in N-terminal to C-terminal direction at least a portion of an immunoglobulin hinge region, which comprises one or more cysteine residues, an immunoglobulin CH2-domain and an immunoglobulin CH3-domain, wherein the first, the second, or the first and the second polypeptide comprise the mutation Y436A (numbering according to the EU index). |
| 申请公布号 |
US2017044246(A1) |
申请公布日期 |
2017.02.16 |
| 申请号 |
US201615210464 |
申请日期 |
2016.07.14 |
| 申请人 |
Hoffmann-La Roche Inc. |
发明人 |
SCHLOTHAUER Tilman |
| 分类号 |
C07K16/22;A61K9/00;A61K45/06;A61K39/395;A61K39/40;C07K16/12 |
主分类号 |
C07K16/22 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A polypeptide comprising
a first polypeptide and a second polypeptide each comprising in N-terminal to C-terminal direction at least a portion of an immunoglobulin hinge region, which comprises one or more cysteine residues, an immunoglobulin CH2-domain, and an immunoglobulin CH3-domain, wherein the first, or the second, or the first and the second polypeptide comprise the mutation Y436A (numbering according to the EU index). |
| 地址 |
Little Falls NJ US |
