发明名称 |
NEW CRYSTAL FORM OF CEFATHIAMIDINE COMPOUND AND PREPARATION METHOD THEREFOR |
摘要 |
A novel crystalline form of Cefathiamidine compound and its preparation method, characterizing in its X-ray powder diffraction pattern and differential scanning calorimetry thermogram. Dissolving Cefathiamidine compound with a purity of 98% or higher in a solvent at a temperature of 30˜45° C. to form a solution, whose concentration is controlled within 0.05˜0.2 g/mL, and then adding a solventing-out agent to the solution, wherein the amount of the solventing-out agent is 3˜5 times (in volume) of that of the solvent; followed by cooling the solution down to 0˜10° C. at a rate of 0.2˜1° C./min; continuing to stir for 1˜3 hours, and separating the obtained solid-liquid suspension to provide a novel crystalline form of Cefathiamidine compound after drying. |
申请公布号 |
US2017044184(A1) |
申请公布日期 |
2017.02.16 |
申请号 |
US201515304824 |
申请日期 |
2015.11.20 |
申请人 |
TIANJIN UNIVERSITY ;HAINAN LINGKANG PHARMACEUTICAL CO., LTD |
发明人 |
HAO Hongxun;TAO Linggang;SUN Zhihong;HOU Baohong;LV Jun;YIN Qiuxiang;WANG Yongli;GONG Junbo;XIE Chuang;BAO Ying |
分类号 |
C07D501/60 |
主分类号 |
C07D501/60 |
代理机构 |
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代理人 |
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主权项 |
1. A novel crystalline form of Cefathiamidine compound, characterized in that, it has an X-ray powder diffraction pattern comprising characteristic diffraction peaks (expressed in degrees 2θ) at 7.26°±0.2°, 8.08°±0.2°, 10.38°±0.2°, 12.64°±0.2°, 13.96°±0.2°, 14.52°±0.2°, 16.60°±0.2°, 19.22°±0.2°, 20.04°±0.2°, 21.14°±0.2°, 21.84°±0.2°, and 22.74°±0.2°. |
地址 |
Tianjin CN |