| 主权项 |
1. A compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein: R is phenyl, —C1-C4 alkylene-phenyl, oxetanyl, C1-C6 alkyl, —C3-C8 monocyclic cycloalkyl, —C1-C4 alkylene-C3-C8 monocyclic cycloalkyl, 3- to 7-membered monocyclic heterocycle, —C1-C4 alkylene 3- to 7-membered monocyclic heterocycle, each of which is unsubstituted or substituted with one or more substituents independently selected from the group consisting of -halo, —CN, —NH2, —OH, oxo, —C1-C4 alkyl, halo-substituted C1-C4 alkyl, amino-substituted C1-C4 alkyl, —NH—C1-C4 alkyl, —NHC(O)—C1-C4 alkyl, —C(O)NH—C1-C4 alkyl, —C(O)N(C1-C4 alkyl)2, hydroxy-substituted C1-C4 alkyl, —S(O)2-C1-C4 alkyl, —S(O)2-halo-substituted C1-C4 alkyl, —S(O)2-NH—C1-C4 alkyl, —S(O)2-N(C1-C4 alkyl)2, —NH—S(O)2-C1-C4 alkyl, —N(C1-C4 alkyl)-S(O)2-C1-C4 alkyl, C1-C4 alkoxy, halo-substituted C1-C4 alkoxy, 3- to 7-membered monocyclic heterocycle, —C3-C8 monocyclic cycloalkyl, —C(O)NH2 and -phenoxy, provided that phenyl is not substituted with one or more oxo; Y is phenyl or pyridinyl which is unsubstituted or substituted with one or more substituents independently selected from the group consisting of -halo, —C1-C4 alkoxy, halo-substituted C1-C4 alkoxy, —C1-C4 alkyl, halo-substituted C1-C4 alkyl, amino-substituted C1-C4 alkoxy, —CN, (C1-C4 alkyl)2N—C1-C4 alkoxy, —NH—C1-C4 alkyl, —OH and —NH2; and Z is —CN or nitrogen-containing 3- to 7-membered monocyclic heterocycle which is unsubstituted or substituted with one or more substituents independently selected from the group consisting of -halo, —CN, —NH2, —OH, —C1-C4 alkyl, halo-substituted C1-C4 alkyl, —C1-C4 alkoxy, —OCF3 and 3- to 7-membered monocyclic heterocycle. |
