| 摘要 |
The present invention is directed to methods, compositions and kits for treatment of cancer, e.g. heptacellular carcinoma. In some embodiments, the present invention discloses the use of a small-molecule compound of formula (I)-(XXVI) and (III′) as disclosed herein to inhibit transcription factor Late SV40 Factor (LSF) for treatment of cancer, e.g., HCC. |
| 主权项 |
1. A compound of formula (III′), wherein the Formula (III′) has the structure: wherein: R1′ is an aryl substituted with at least one C1-C6 alkoxyl and at least one di(C1-C24alkyl)amino, wherein the substituted aryl can be optionally further substituted with halogen, C1-C4 alkyl, C1-C4haloalkyl, C1-C4 heteroalkyl, di(C1-C24alkyl)amino or combinations thereof; R2 and R3 are hydrogen or R2 and R3 together form a second bond between the carbons to which they are attached; R4 is hydrogen; R5 is selected from the group consisting of hydrogen and C1-C6 alkyl; R6 and R7 are each independently selected from the group consisting of hydrogen, F, Br, Cl and I; R10 and R11 are each independently selected from the group consisting of hydrogen, F, Br, Cl, and I; or enantiomers, prodrugs, derivatives, and pharmaceutically acceptable salts thereof, and wherein the compound is capable of inhibiting late SV40 factor (LSF). |
