摘要 |
Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR40 receptor. Such compounds are represented by Formula (I), as follows:;;wherein R1, R2, R4, W, X, Y, and G, are defined herein. |
主权项 |
1. A compound of Formula (I) wherein
X is S or O; provided that when X is O, Y is N;Y is C(R3) or N;R3 is hydrogen or methyl; or when X is S, R3 is hydrogen, methyl, or chloro;W is CH or N;L is —CH2O—, —CH═CH—, or —(CH2)1-2—;R1 is selected from the group consisting of phenyl, pyridin-4-yl, thienyl, benzothiophenyl, benzofuranyl, and indolyl; wherein said benzothiophenyl, benzofuranyl, and indolyl are attached to the core (X)-(Y) containing ring via its benzo ring; and wherein R1 is optionally independently substituted with one or two substituents selected from C1-4alkyl, methoxy, fluoro, cyano, di(C1-4alkyl)amino, or trifluoromethyl;R2 is C3-5cycloalkyl, C1-6alkyl, or cyano;R4 is hydrogen or chloro;G is selected from the group consisting of C1-6alkyl, C1-6alkoxy, phenyl, unsubstituted C3-7cycloalkyl, unsubstituted C3-7cycloalkoxy, unsubstituted C3-7cycloalkyl-methoxy, C2-6alk-1-en-1-yl, 3,3,3-trifluoropropoxy, 2,2,2-trifluoro-1-methyl-ethyl, (C1-6alkyl)thien-2-yl, and a substituent selected from g1 to g6; or an enantiomer, diastereomer, or pharmaceutically acceptable salt form thereof. |