Parasiticidal oral veterinary compositions comprising systemically-acting active agents, methods and uses thereof

摘要

This invention relates to oral veterinary compositions for combating ectoparasites and endoparasites in animals, comprising at least one systemically-acting active isoxazoline agent in combination with a pharmaceutically acceptable carrier. This invention also provides for improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof. WO 2013/119442 PCT/US2013/023969 120 - - - - - - - 100 ----------- - - 80 J------------- ---.--- - - - - - - - - - Initial --- +-- 1 Months 60 + - - - - - - - - -- A-- 2 Months - -3 Months 40 - - - - - - - - - -P- 6 Months --- 12 Months 20 ------------------ 0 o - - - - .- - .- - .- - - .- 0 20 40 60 80 100 120 Time (minutes) Figure 1: Average Dissolution of 2g Chewables Stored at 250 C/60%RH 1 20--- ----- ----- ----- - - - - - - - - - - - - - - - - ---- --- ----- ---- ----- ----- ---- ----- ----- ----- ---- ----- ----- ---- ----- ----- -- 100 -------------- --- -U-Initial 60 +------------ ------------------- ------------------------------ - 2 Months -- A--4 Months 40 -- -- ----- -. O -6 Months 20 ------------------- 0 20 40 60 80 100 120 Time (minutes) Figure 2. Average Dissolution of 2g Chewables Stored at 400 C/75%RH .l JR.TITI JTF .HFFT (IJ 11 F 9A'