RESONATOR AND PROCESS FOR PERFORMING BIOLOGICAL ASSAY

摘要

A process for assaying a biological sample includes: receiving a reference sample by an acoustic article including: a resonator including: a substrate; a piezoelectric member; and a phase noise detector; disposing the reference sample on the piezoelectric member; producing a reference phase noise signal; detecting the reference phase noise signal; disposing a biological sample on the piezoelectric member; producing a first biological phase noise signal; detecting the first biological phase noise signal; contacting the biological sample disposed on the piezoelectric member with an antimicrobial agent; producing a second biological phase noise signal; detecting the second biological phase noise signal; and analyzing the first biological phase noise signal, the second biological phase noise signal, and the reference phase noise signal to assay the biological sample.

主权项

1. An acoustic article for assaying a biological sample, the article comprising:
a resonator comprising:
a substrate comprising an inverted mesa structure;a piezoelectric member disposed on the substrate to receive the biological sample and to produce a phase noise signal, the phase noise signal indicating activity of the biological sample; and a phase noise detector in electrical communication with the piezoelectric member to receive the phase noise signal from the piezoelectric member and to produce a phase noise spectrum in response to receiving the phase noise signal from the piezoelectric member.