| 发明名称 |
METHODS AND COMPOSITIONS FOR TREATING METASTATIC BREAST CANCER AND OTHER CANCERS IN THE BRAIN |
| 摘要 |
A composition comprising at least one AAV vector formulated for central nervous system delivery is described. The composition comprises at least one expression cassette which contains sequences encoding an anti-neoplastic immunoglobulin construct for delivery to the brain operably linked to expression control sequences therefor and a pharmaceutically acceptable carrier. The anti-neoplastic immunoglobulin construct may be an immunoglobulin modified to have decreased or no measurable affinity for neonatal Fc receptor (FcRn). Also provided are methods of using these constructs in preparing pharmaceutical compositions and uses thereof in anti-neoplastic regimens, particularly for primary and/or metastatic cancers of the brain. |
| 申请公布号 |
US2017043035(A1) |
申请公布日期 |
2017.02.16 |
| 申请号 |
US201515306413 |
申请日期 |
2015.04.24 |
| 申请人 |
The Trustees of the University of Pennsylvania |
发明人 |
Wilson James M.;Rothwell William Thomas;Hinderer Christian |
| 分类号 |
A61K48/00;A61K9/00;C07K16/32 |
主分类号 |
A61K48/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A composition comprising at least one AAV vector formulated for central nervous system delivery, wherein said composition comprises at least one expression cassette which contains sequences encoding an anti-neoplastic immunoglobulin construct for delivery to the brain operably linked to expression control sequences therefor and a pharmaceutically acceptable carrier. |
| 地址 |
Philadelphia PA US |
