| 摘要 |
A class of polycyclic compounds of general formula (I), of general formula (I'), or of general formula (I"), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, and R8a are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds. |
| 申请人 |
MERCK SHARP & DOHME CORP.;ALTMAN, Michael, D.;ANDRESEN, Brian;CHANG, Wonsuk;CHILDERS, Matthew Lloyd;CUMMING, Jared, N.;HAIDLE, Andrew Marc;HENDERSON, Timothy, J.;JEWELL, James, P.;LIANG, Rui;LIM, Jongwon;LIU, Hong;LU, Min;NORTHRUP, Alan, B.;OTTE, Ryan, D.;SIU, Tony;TROTTER, Benjamin Wesley;TRUONG, Quang, T.;WALSH, Shawn, P.;ZHAO, Kake |
发明人 |
ALTMAN, Michael, D.;ANDRESEN, Brian;CHANG, Wonsuk;CHILDERS, Matthew Lloyd;CUMMING, Jared, N.;HAIDLE, Andrew Marc;HENDERSON, Timothy, J.;JEWELL, James, P.;LIANG, Rui;LIM, Jongwon;LIU, Hong;LU, Min;NORTHRUP, Alan, B.;OTTE, Ryan, D.;SIU, Tony;TROTTER, Benjamin Wesley;TRUONG, Quang, T.;WALSH, Shawn, P.;ZHAO, Kake |
