INHIBITORS OF DRUG-RESISTANT MYCOBACTERIUM TUBERCULOSIS

摘要

The present invention provides novel indoleamide compounds for treating tuberculosis, including drug-resistant M-tuberculosis, compositions comprising the indoleamides and methods of using the indoleamides in conjunction with other biologically active agents for the treatment of tuberculosis in a subject in need thereof.

主权项

1. A compound of formula I:wherein
R1, R2, R3 and R4 are independently selected from H, alkyl, haloalkyl, alkoxy, halo and amino; X is CH, N or S; Y is O or NR5; L is absent or C1-C4 alkyl; R6 is H or alkyl; R7 is C3-C12 cycloalkyl, C3-C12, C5-C8 heterocyclyl, C6 aryl, C5-C6 heteroaryl or substituted or unsubstituted C3-C12 alkyl, or R6 and R7 together form a C5-C8 heterocyclyl; and Rs is H or alkyl, or a pharmaceutically acceptable salt, solvate or stereoisomer thereof.