发明名称 |
COMPOSITIONS COMPRISING CYCLODEXTRIN INCORPORATED COLLAGEN MATRICES FOR USE IN BIOMEDICAL APPLICATIONS |
摘要 |
The present inventors employed cyclodextrins for use as a proteoglycan substitute to engineer a biomimetic collagen-based matrix composition. The resulting incorporation of cyclodextrin in the inventive collagen compositions increased collagen thermal stability and reduced collagen fibrogenesis. As a result, a thick, transparent and mechanically strong collagen-based composition was formed. This cyclodextrin-collagen composition holds a great potential to be used as a therapeutic eye patch for corneal repair. Methods for making these inventive compositions and their use are also provided. |
申请公布号 |
US2017043021(A1) |
申请公布日期 |
2017.02.16 |
申请号 |
US201515306159 |
申请日期 |
2015.04.24 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY |
发明人 |
Elisseeff Jennifer H.;Guo Qiongyu;Majumdar Shoumyo |
分类号 |
A61K47/42;A61K47/40;A61K9/00;A61K9/06 |
主分类号 |
A61K47/42 |
代理机构 |
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代理人 |
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主权项 |
1. A composition comprising a vitrified matrix gel having a first component and a second component, wherein the first component comprises collagen, and wherein the second component comprises cyclodextrin. |
地址 |
Baltimore MD US |