VACCINES FOR PROTECTION FROM AND TREATMENT OF ALZHEIMER'S DISEASE

摘要

Disclosed herein are DNA-based vaccines against amyloid β peptide for use in treating and alleviating Alzheimer's Disease and related conditions. A DNA construct comprising DNA encoding one or more amyloid β peptides, such as amino acids 1-11 of Aβ, and DNA encoding a hepatitis B antigens, is administered with an adjuvant or by electroporation. The vaccine can also be formulated using a fusion protein expressed by the disclosed DNA, in combination with an adjuvant.

主权项

1. A DNA vaccine comprising a DNA plasmid containing and expressing in vivo a polynucleotide, wherein said polynucleotide comprises (i) a polynucleotide sequence encoding an antigenic polypeptide, (ii) a polynucleotide sequence encoding a T-helper epitope of hepatitis B virus capsid antigen; and (iii) a polynucleotide of S gene of hepatitis B virus, wherein said antigenic polypeptide comprises a fragment of amyloid-β protein.