发明名称 |
CRISPR-BASED COMPOSITIONS AND METHODS OF USE |
摘要 |
This invention pertains to modified compositions for use in CRISPR systems, and their methods of use. In particular, length-modified and chemically-modified forms of crRNA and tracrRNA are described for use as a reconstituted guide RNA for interaction with Cas9 of CRISPR systems. The resultant length-modified and chemically-modified forms of crRNA and tracrRNA are economical to produce and can be tailored to have unique properties relevant to their biochemical and biological activity in the context of the CRISPR Cas9 endonuclease system. |
申请公布号 |
US2017044536(A1) |
申请公布日期 |
2017.02.16 |
申请号 |
US201615299590 |
申请日期 |
2016.10.21 |
申请人 |
INTEGRATED DNA TECHNOLOGIES, INC. |
发明人 |
Collingwood Michael Allen;Jacobi Ashley Mae;Rettig Garrett Richard;Schubert Mollie Sue;Behlke Mark Aaron |
分类号 |
C12N15/113 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Skokie IL US |