ANTI-PD1 ANTIBODIES, ACTIVATABLE ANTI-PD1 ANTIBODIES, AND METHODS OF USE THEREOF

摘要

The invention relates generally to antibodies that specifically bind programmed cell death protein 1 (PD-1), activatable antibodies that specifically bind to PD-1 and methods of making and using these anti-PD-1 antibodies and anti-PD-1 activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.

主权项

1. An isolated antibody or antigen binding fragment thereof (AB) that specifically binds to mammalian PD-1, wherein the AB has one or more of the characteristics selected from the group consisting of:
(a) the AB inhibits binding of mammalian PD-1 to mammalian PDL1 with an EC50 value less than 5 nM; (b) the AB inhibits binding of mammalian PD-1 to mammalian PDL2 with an EC50 value less than 5 nM; and (c) the AB specifically binds to human PD-1 and cynomolgus monkey PD-1.