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1. A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein: R1 is H, C1-4 alkyl, or C1-4 haloalkyl; R2 is C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-4 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C3-10 cycloalkyl-C1-4 alkylene, 4-10 membered heterocycloalkyl-C1-4 alkylene, 6-10 membered aryl-C1-4 alkylene, or 5-10 membered heteroaryl-C1-4 alkylene; each of which is optionally substituted by 1, 2, 3, or 4 independently selected R21 groups; R3 is H, halo, CN, OH, C1-6 alkyl, C1-4 haloalkyl, C1-6 alkoxy, C1-4 haloalkoxy, amino, C1-6 alkylamino, or di(C1-6 alkyl)amino; L is —C1-6 alkylene-, —Y—, —C1-6 alkylene-Y—, —Y—C1-6 alkylene-, or —C1-4 alkylene-Y—C1-4 alkylene-; wherein said alkylene groups are each optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, OH, C1-3 alkyl, C1-3 alkoxy, C1-3 haloalkyl, C1-3 haloalkoxy, amino, C1-3 alkylamino, and di(C1-3 alkyl)amino; Y is O, S, S(O), S(O)2, C(O), C(O)NRf, NRfC(O), S(O)2NRf, NRfS(O)2, or NRf; each Rf is independently selected from H and C1-3 alkyl; n is 0 or 1; CyA is C3-7 cycloalkyl, phenyl, 5-6 membered heteroaryl, or 4-6 membered heterocycloalkyl, each of which is optionally substituted by 1, 2, 3, or 4 independently selected RA groups; each RA is independently selected from OH, NO2, CN, halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-4 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, cyano-C1-3 alkyl, HO—C1-3 alkyl, amino, C1-6 alkylamino, di(C1-6 alkyl)amino, thio, C1-6 alkylthio, C1-6 alkylsulfinyl, C1-6 alkylsulfonyl, carbamyl, C1-6 alkylcarbamyl, di(C1-6 alkyl)carbamyl, carboxy, C1-6 alkylcarbonyl, C1-6 alkoxycarbonyl, C1-6 alkylcarbonylamino, C1-6 alkylsulfonylamino, aminosulfonyl, C1-6 alkylaminosulfonyl, di(C1-6 alkyl)aminosulfonyl, aminosulfonylamino, C1-6 alkylaminosulfonylamino, di(C1-6 alkyl)aminosulfonylamino, aminocarbonylamino, C1-6 alkylaminocarbonylamino, di(C1-6 alkyl)aminocarbonylamino, C3-7 cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-6 membered heterocycloalkyl, C3-7 cycloalkyl-C1-3 alkylene, phenyl-C1-3 alkylene, 5-6 membered heteroaryl-C1-3 alkylene, and 4-6 membered heterocycloalkyl-C1-3 alkylene; wherein each said C1-6 alkyl, C3-7 cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-6 membered heterocycloalkyl, C3-7 cycloalkyl-C1-3 alkylene, phenyl-C1-3 alkylene, 5-6 membered heteroaryl-C1-3 alkylene, and 4-6 membered heterocycloalkyl-C1-3 alkylene of substituent RA are optionally substituted with 1, 2, 3, or 4 independently selected R11 groups; CyB is C3-10 cycloalkyl, 6-10 membered aryl, 5-10 membered heteroaryl, or 4-10 membered heterocycloalkyl, each of which is optionally substituted by 1, 2, 3, or 4 independently selected RB groups; each RB is independently selected from halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-4 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C3-10 cycloalkyl-C1-4 alkylene, 4-10 membered heterocycloalkyl-C1-4 alkylene, 6-10 membered aryl-C1-4 alkylene, 5-10 membered heteroaryl-C1-4 alkylene, CN, NO2, ORa2, SRa2, C(O)Rb2, C(O)NRc2Rd2, C(O)ORa2, OC(O)Rb2, OC(O)NRc2Rd2, NRc2Rd2, NRc2ORd2, NRc2C(O)Rb2, NRc2C(O)ORa2, C(═NRe)Rb2, C(═NRe)NRc2Rd2, NRc2C(═NRe)NRc2Rd2, NRc2C(O)NRc2Rd2, NRc2S(O)Rb2, NRc2S(O)2Rb2, NRc2S(O)2NRc2Rd2, S(O)Rb2, S(O)2Rb2, S(O)NRc2Rd2, and S(O)2NRc2Rd2; wherein each said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-4 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C3-10 cycloalkyl-C1-4 alkylene, 4-10 membered heterocycloalkyl-C1-4 alkylene, 6-10 membered aryl-C1-4 alkylene, and 5-10 membered heteroaryl-C1-4 alkylene are optionally substituted with 1, 2, 3, or 4 independently selected R12 groups; each R11 is independently selected from OH, CN, halo, C1-4 alkyl, C1-3 haloalkyl, C1-4 alkoxy, C1-3 haloalkoxy, cyano-C1-3 alkyl, HO—C1-3 alkyl, amino, C1-4 alkylamino, di(C1-4 alkyl)amino, C1-4 alkylsulfinyl, C1-4 alkylsulfonyl, carbamyl, C1-4 alkylcarbamyl, di(C1-4 alkyl)carbamyl, carboxy, C1-4 alkylcarbonyl, C1-4 alkoxycarbonyl, C1-4 alkylcarbonylamino, C1-4 alkylsulfonylamino, aminosulfonyl, C1-4 alkylaminosulfonyl, and di(C1-4 alkyl)aminosulfonyl; each R12 is independently selected from halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-4 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C3-10 cycloalkyl-C1-4 alkylene, 4-10 membered heterocycloalkyl-C1-4 alkylene, 6-10 membered aryl-C1-4 alkylene, 5-10 membered heteroaryl-C1-4 alkylene, ORa3, SRa3, C(O)Rb3, C(O)NRc3Rd3, C(O)ORa3, OC(O)Rb3, OC(O)NRc3Rd3, NRc3Rd3, NRc3ORd3, NRc3C(O)Rb3, NRc3C(O)ORa3, NRc3C(O)NRc3Rd3, NRc3S(O)Rb3, NRc3S(O)2Rb3, NRc3S(O)2NRc3Rd3, S(O)Rb3, S(O)NRc3Rd3, S(O)2Rb3, and S(O)2NRc3Rd3; wherein each said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-4 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C3-10 cycloalkyl-C1-4 alkylene, 4-10 membered heterocycloalkyl-C1-4 alkylene, 6-10 membered aryl-C1-4 alkylene, and 5-10 membered heteroaryl-C1-4 alkylene of substituent R12 are optionally substituted with 1, 2, 3, or 4 independently selected R13 groups; each R13 is independently selected from halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-4 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C3-10 cycloalkyl-C1-4 alkylene, 4-10 membered heterocycloalkyl-C1-4 alkylene, 6-10 membered aryl-C1-4 alkylene, 5-10 membered heteroaryl-C1-4 alkylene, ORa4, SRa4, C(O)Rb4, C(O)NRc4Rd4, C(O)ORa4, OC(O)Rb4, OC(O)NRc4Rd4, NRc4Rd4, NRc4ORd4, NRc4C(O)Rb4, NRc4C(O)ORa4, NRc4C(O)NRc4Rd4, NRc4S(O)Rb4, NRc4S(O)2Rb4, NRc4S(O)2NRc4Rd4, S(O)Rb4, S(O)NRc4Rd4, S(O)2Rb4, and S(O)2NRc4Rd4; wherein each said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-4 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C3-10 cycloalkyl-C1-4 alkylene, 4-10 membered heterocycloalkyl-C1-4 alkylene, 6-10 membered aryl-C1-4 alkylene, and 5-10 membered heteroaryl-C1-4 alkylene of substituent R13 are optionally substituted with 1, 2, 3, or 4 independently selected Rg groups; each R21 is independently selected from OH, NO2, CN, halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-4 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, cyano-C1-3 alkyl, HO—C1-3 alkyl, amino, C1-6 alkylamino, di(C1-6 alkyl)amino, thio, C1-6 alkylthio, C1-6 alkylsulfinyl, C1-6 alkylsulfonyl, carbamyl, C1-6 alkylcarbamyl, di(C1-6 alkyl)carbamyl, carboxy, C1-6 alkylcarbonyl, C1-6 alkoxycarbonyl, C1-6 alkylcarbonylamino, C1-6 alkylsulfonylamino, aminosulfonyl, C1-6 alkylaminosulfonyl, di(C1-6 alkyl)aminosulfonyl, aminosulfonylamino, C1-6 alkylaminosulfonylamino, di(C1-6 alkyl)aminosulfonylamino, aminocarbonylamino, C1-6 alkylaminocarbonylamino, di(C1-6 alkyl)aminocarbonylamino, C3-7 cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-6 membered heterocycloalkyl, C3-7 cycloalkyl-C1-3 alkylene, phenyl-C1-3 alkylene, 5-6 membered heteroaryl-C1-3 alkylene, and 4-6 membered heterocycloalkyl-C1-3 alkylene; wherein each said C1-6 alkyl, C3-7 cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-6 membered heterocycloalkyl, C3-7 cycloalkyl-C1-3 alkylene, phenyl-C1-3 alkylene, 5-6 membered heteroaryl-C1-3 alkylene, and 4-6 membered heterocycloalkyl-C1-3 alkylene of substituent R21 are optionally substituted with 1, 2, 3, or 4 groups independently selected from OH, CN, halo, C1-4 alkyl, C1-3 haloalkyl, C1-4 alkoxy, C1-3 haloalkoxy, cyano-C1-3 alkyl, HO—C1-3 alkyl, amino, C1-4 alkylamino, di(C1-4 alkyl)amino, C1-4 alkylsulfinyl, C1-4 alkylsulfonyl, carbamyl, C1-4 alkylcarbamyl, di(C1-4 alkyl)carbamyl, carboxy, C1-4 alkylcarbonyl, C1-4 alkoxycarbonyl, C1-4 alkylcarbonylamino, C1-4 alkylsulfonylamino, aminosulfonyl, C1-4 alkylaminosulfonyl, and di(C1-4 alkyl)aminosulfonyl; each Re is independently selected from H, CN, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkylthio, C1-6 alkylsulfonyl, C1-6 alkylcarbonyl, C1-6 alkylaminosulfonyl, carbamyl, C1-6 alkylcarbamyl, di(C1-6 alkyl)carbamyl, aminosulfonyl, C1-6 alkylaminosulfonyl, and di(C1-6 alkyl)aminosulfonyl; each Ra2, Rc2, and Rd2 is independently selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-4 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C3-10 cycloalkyl-C1-4 alkylene, 4-10 membered heterocycloalkyl-C1-4 alkylene, 6-10 membered aryl-C1-4 alkylene, and 5-10 membered heteroaryl-C1-4 alkylene; wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-4 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C3-10 cycloalkyl-C1-4 alkylene, 4-10 membered heterocycloalkyl-C1-4 alkylene, 6-10 membered aryl-C1-4 alkylene, and 5-10 membered heteroaryl-C1-4 alkylene are each optionally substituted with 1, 2, 3, or 4 independently selected R12 groups; each Rb2 is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-4 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C3-10 cycloalkyl-C1-4 alkylene, 4-10 membered heterocycloalkyl-C1-4 alkylene, 6-10 membered aryl-C1-4 alkylene, and 5-10 membered heteroaryl-C1-4 alkylene; each of which is optionally substituted with 1, 2, 3, or 4 independently selected R12 groups; or alternatively, any Rc2 and Rd2 attached to the same N atom, together with the N atom to which they are attached, form a 4-, 5-, 6- or 7-membered heterocycloalkyl group optionally substituted with 1, 2 or 3 independently selected R12 groups; each Ra3, Rc3, and Rd3 is independently selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-4 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C3-10 cycloalkyl-C1-4 alkylene, 4-10 membered heterocycloalkyl-C1-4 alkylene, 6-10 membered aryl-C1-4 alkylene, and 5-10 membered heteroaryl-C1-4 alkylene; wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-4 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C3-10 cycloalkyl-C1-4 alkylene, 4-10 membered heterocycloalkyl-C1-4 alkylene, 6-10 membered aryl-C1-4 alkylene, and 5-10 membered heteroaryl-C1-4 alkylene are each optionally substituted with 1, 2, 3, or 4 independently selected R13 groups; each Rb3 is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-4 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C3-10 cycloalkyl-C1-4 alkylene, 4-10 membered heterocycloalkyl-C1-4 alkylene, 6-10 membered aryl-C1-4 alkylene, and 5-10 membered heteroaryl-C1-4 alkylene; each of which is optionally substituted with 1, 2, 3, or 4 independently selected R13 groups; or alternatively, any Rc3 and Rd3 attached to the same N atom, together with the N atom to which they are attached, form a 4-, 5-, 6- or 7-membered heterocycloalkyl group optionally substituted with 1, 2 or 3 independently selected R13 groups; each Ra4, Rc4, and Rd4 is independently selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-4 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C3-10 cycloalkyl-C1-4 alkylene, 4-10 membered heterocycloalkyl-C1-4 alkylene, 6-10 membered aryl-C1-4 alkylene, and 5-10 membered heteroaryl-C1-4 alkylene; wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-4 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C3-10 cycloalkyl-C1-4 alkylene, 4-10 membered heterocycloalkyl-C1-4 alkylene, 6-10 membered aryl-C1-4 alkylene, and 5-10 membered heteroaryl-C1-4 alkylene are each optionally substituted with 1, 2, 3, or 4 independently selected Rg groups; each Rb4 is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-4 haloalkyl, C3-10 cycloalkyl, 6-10 membered aryl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C3-10 cycloalkyl-C1-4 alkylene, 4-10 membered heterocycloalkyl-C1-4 alkylene, 6-10 membered aryl-C1-4 alkylene, and 5-10 membered heteroaryl-C1-4 alkylene; each of which is optionally substituted with 1, 2, 3, or 4 independently selected Rg groups; or alternatively, any Rc4 and Rd4 attached to the same N atom, together with the N atom to which they are attached, form a 4-, 5-, 6- or 7-membered heterocycloalkyl group optionally substituted with 1, 2 or 3 independently selected Rg groups; each Rg is independently selected from OH, NO2, CN, halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-4 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, cyano-C1-3 alkyl, HO—C1-3 alkyl, amino, C1-6 alkylamino, di(C1-6 alkyl)amino, thio, C1-6 alkylthio, C1-6 alkylsulfinyl, C1-6 alkylsulfonyl, carbamyl, C1-6 alkylcarbamyl, di(C1-6 alkyl)carbamyl, carboxy, C1-6 alkylcarbonyl, C1-6 alkoxycarbonyl, C1-6 alkylcarbonylamino, C1-6 alkylsulfonylamino, aminosulfonyl, C1-6 alkylaminosulfonyl, di(C1-6 alkyl)aminosulfonyl, aminosulfonylamino, C1-6 alkylaminosulfonylamino, di(C1-6 alkyl)aminosulfonylamino, aminocarbonylamino, C1-6 alkylaminocarbonylamino, and di(C1-6 alkyl)aminocarbonylamino. |
