| 发明名称 |
Methods and Compositions to Modulate RNA Processing |
| 摘要 |
The present disclosure provides methods and compositions to selectively modulate RNA processing. The methods and compositions selectively enhance or repress RNA processing by up- or down-regulating Drosha expression and/or by providing RNA sequences with mismatches introduced or removed 5 and/or 9-12 nucleotide positions from the Drosha cutting site. Therapeutic uses of the methods and compositions are also described. |
| 申请公布号 |
US2017044529(A1) |
申请公布日期 |
2017.02.16 |
| 申请号 |
US201615166085 |
申请日期 |
2016.05.26 |
| 申请人 |
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION |
发明人 |
Ruohola-Baker Hannele;Banik Pratyusha;Beem Alan;Shannon Sandra;Sperber Henrik |
| 分类号 |
C12N15/113 |
主分类号 |
C12N15/113 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An expression vector encoding an endogenous RNA-based molecule altered to encode at least one mis-match at nucleotide position 5, 9, 10, 11 or 12 from the RNA's Drosha cutting site. |
| 地址 |
Seattle WA US |
