| 主权项 |
1. An immunogenic molecular entity comprising at least one hapten linked to a macromolecular carrier, wherein the hapten comprises a cyclic peptide comprising a macrocyclic ring, wherein the cyclic peptide comprises the amino acid sequence selected from the group consisting of GVNP(Xa+2)GGWF (SEQ ID NO: 96), KAKT(Xa+2)TVLY (SEQ ID NO: 97), KTKT(Xa+2)TVLY (SEQ ID NO: 98), GANP(Xa+2)OLYY (SEQ ID NO: 99), GANP(Xa+2)ALYY (SEQ ID NO: 100), GYST(Xa+2)SYYF (SEQ ID NO: 101), GYRT(Xa+2)NTYF (SEQ ID NO: 102), YNP(Xa+2)VGYF (SEQ ID NO: 103), GGKV(Xa+2)SAYF (SEQ ID NO: 104), SVKP(Xa+2)TGFA (SEQ ID NO: 105), DSV(Xa+2)ASYF (SEQ ID NO: 106), KYNP(Xa+2)SNYL (SEQ ID NO: 107), KYNP(Xa+2)ASYL (SEQ ID NO: 108), KYNP(Xa+2)ANYL (SEQ ID NO: 109), RIPT(Xa+2)TGFF (SEQ ID NO: 110), DI(Xa+2)NAYF (SEQ ID NO: 111), DM(Xa+2)NGYF (SEQ ID NO: 112), KYNP(Xa+2)LGFL (SEQ ID NO: 113), KYYP(Xa+2)FGYF (SEQ ID NO: 114), GARP(Xa+2)GGFF (SEQ ID NO: 115), GAKP(Xa+2)GGFF (SEQ ID NO: 116), YSP(Xa+2)TNFF (SEQ ID NO: 117), YSP(Xa+2)TNF (SEQ ID NO: 118), or QN(Xa+2)PNIFGQWM (SEQ ID NO: 119),
wherein the last amino acid residue of each sequence is X1 which is an amino acid residue that is covalently bonded to a group R by a respective carbonyl group; Xa+2 is any amino acid, a respective carbon atom of which is covalently bonded to R; wherein R comprises —CH2O—, —CH2CH2O—, —CH2CH(CH3)O—, —CH2-phenyl-O—, —CH2S—, —CH2CH2S—, or —(CH2)nNH—, wherein n is 1 to about 4; and wherein the N-terminal amino acid residue of the cyclic peptide is attached to the macromolecular carrier. |
