| 发明名称 |
COMPOSITIONS AND METHODS FOR TREATING HEPATITIS B |
| 摘要 |
The present invention provides compositions and methods for treating hepatitis B virus (HBV) infection as well as methods for identifying a compound or a composition that is suitable for treating HBV infection. In addition, the present invention provides a suitable non-mammalian animal model that can be used to screen for a compound or a composition that can inhibit HBV replication or treat HBV infection in a mammal. In particular, the present invention provides compositions and methods for treating hepatitis B infection by inhibiting interaction between HBV x protein and a Bcl-2 family protein or by reducing the expression level of a Bcl-2 family protein. |
| 申请公布号 |
US2017042960(A1) |
申请公布日期 |
2017.02.16 |
| 申请号 |
US201615343473 |
申请日期 |
2016.11.04 |
| 申请人 |
The Regents of the University of Colorado, a body corporate |
发明人 |
Xue Ding;Geng Xin |
| 分类号 |
A61K38/04;G01N33/50;C12N15/113 |
主分类号 |
A61K38/04 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for treating hepatitis B infection in a subject, said method comprising administering to a subject in need of such a treatment a composition (i) that is capable of inhibiting binding of hepatitis B virus X protein to a Bcl-2 family member protein in said subject; (ii) that is capable of reducing the expression of Bcl-2 family member protein in said subject; or (iii) a combination thereof. |
| 地址 |
Denver CO US |
