| 发明名称 |
ATROPISOMERISM FOR INCREASED KINASE INHIBITOR SELECTIVITY |
| 摘要 |
The invention provides a series of conformationally stable kinase inhibitors, and methods of using the kinase inhibitors. The effect of atropisomerism on kinase selectivity was assessed, finding improved selectivity compared to rapidly interconverting parent compounds. |
| 申请公布号 |
WO2017027883(A1) |
申请公布日期 |
2017.02.16 |
| 申请号 |
WO2016US47085 |
申请日期 |
2016.08.15 |
| 申请人 |
SAN DIEGO STATE UNIVERSITY RESEARCH FOUNDATION |
发明人 |
GUSTAFSON, Jeffrey L.;SMITH, David E.;HECHT, David;MARQUEZ, Isaac;TOENJES, Sean |
| 分类号 |
A61K31/505;A61K31/519;C07D487/04 |
主分类号 |
A61K31/505 |
| 代理机构 |
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