| 摘要 |
PROBLEM TO BE SOLVED: To asymmetrically synthesize constituent optically active substances of doranidazole and clarify pharmacological and physicochemical features of each of the optically active substances.SOLUTION: A method of producing a compound of structural formula (1) comprises condensing trimethylsilyl-2-nitroimidazole with a specified polyhydric alcohol derivative in the presence of a catalyst and deprotecting to obtain ((2S3R)-3-(2-nitroimidazol-1-ylmethoxy)butane-1,2,4-triol). |
