发明名称 |
SEPARATION OF RECOMBINANT POLYCLONAL ANTIBODY MULTIMERS WITH MINIMAL SEPARATION OF MONOMERS |
摘要 |
The invention provides a method for removing multimers from a preparation of recombinant polyclonal antibodies (rpAbs) while maintaining the ratio of monomers within a narrow range. The invention provides a method of separating recombinant polyclonal antibody multimers with minimal separation of monomers comprising subjecting a mixture comprising a plurality of monoclonal antibodies to at least one separation process selected from the group consisting of multi-modal chromatography, apatite chromatography, and hydrophobic interaction chromatography thereby producing an antibody monomer preparation that is substantially free of multimers. |
申请公布号 |
EP2997041(A4) |
申请公布日期 |
2017.02.15 |
申请号 |
EP20140818351 |
申请日期 |
2014.05.12 |
申请人 |
MedImmune, LLC |
发明人 |
HUNTER, Alan;PABST, Timothy;WANG, Jihong;WANG, Xiangyang;LIU, Hongji |
分类号 |
C07K16/00;B01D15/26;B01D15/32;B01D15/38;C07K1/16;C07K16/06 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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