Method and system for non-invasive optical blood glucose detection utilizing spectral data analysis

摘要

Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. This includes utilizing at least one light source configured to strike a target area of a sample, utilizing at least one light filter positioned to receive light transmitted through the target area of the sample from the at least one light source, utilizing at least one light detector positioned to receive light from the at least one light source and filtered by the at least one light filter, and to generate an output signal, having a time dependent current, which is indicative of the power of light detected, receiving the output signal from the at least one light detector with a processor, calculating the attenuance attributable to blood with a ratio factor based on the received output signal, and determining a blood glucose level based on the calculated attenuance.

主权项

1. A system for detecting glucose in a biological sample, comprising:
at least one light source configured to generate one or more light beams having a wavelength in a range between 800 nm and 1600 nm and to strike a target area of a sample; at least one photocurrent signal generating light detector positioned to receive light from the at least one light source and to generate an output photocurrent signal, having a time dependent current, which is indicative of the power of light detected; and a light absorbance change determining algorithm implemented processor programmed to calculate a change in a light absorption caused by blood in the biological sample and configured to receive the output photocurrent signal from the at least one photocurrent signal generating light detector and based on the received output photocurrent signal, calculate the attenuance attributable to blood in a sample present in the target area with a ratio factor, and based on the calculated attenuance, determine a blood glucose level associated with a sample present in the target area; wherein the light absorbance change determining algorithm implemented processor is configured to calculate the ratio factor using a standard deviation of a logarithm of the time dependent output photocurrent current generated by the light power from the same target area of the biological sample, wherein the light absorbance change determining algorithm implemented processor is configured to calculate the ratio factor Yij(C,T) at a plurality of wavelengths, the ith wavelength being represented by λi, the jth wavelength being represented by λj, C is a blood glucose concentration, T is temperature of the biological sample, ID (λi, t) is the time dependent output current, σ[log ID(λi,t)] is standard deviation of the logarithm of the time dependent output current, and t is time, according to the equation:Yij⁡(C,T)=σ⁡[log⁢⁢ID⁡(λi,t)]σ⁡[log⁢⁢ID⁡(λj,t)].