método para identificar um agente que diminui seletivamente o número de células-tronco com câncer, método de classificação de resultado máximo para identificação de agentes, agente para matar seletivamente cscs e composição farmacêutica

摘要

The present invention provides, inter alia, a method for identifying an agent that selectively decreases the number of cancer stem cells (CSCs). This method includes (a) contacting a CSC from a population of cells with a candidate agent; and (b) determining whether the candidate agent reduces the survival or growth of the CSC or increases differentiation of the CSC relative to a CSC that has not been contacted with the candidate agent. The method may be used as a high throughput screen.