Multi-layered anti-adhesion device

摘要

Compositions and methods are provided for preparing an adhesion barrier in the form of a foldable or flexible biodegradable polymer matrix that effectively reduces, prevents or treats adhesions in a patient in need thereof. In one embodiment, the matrix comprises a first porous layer comprising collagen and a second porous layer comprising collagen and dextran, wherein the dextran is loaded in the second layer in an amount of from about 5% to about 90% by weight based on a total weight of the matrix. In some embodiments, the matrix prevents or reduces cell growth into the matrix so as to reduce or prevent adhesions. In some embodiments, the matrix is in a sheet or strip form that can be folded into a tube form.

主权项

1. A foldable or flexible biodegradable polymer matrix for reducing, preventing or treating adhesions in a patient in need thereof, the matrix comprising a first porous layer comprising collagen and a second porous layer comprising collagen and dextran, wherein the dextran is loaded in the second layer in an amount of from about 5% to about 90% by weight based on a total weight of the matrix and the matrix reduces cell growth therein, and the matrix is configured to be folded into a wrap and configured to release from about 20% to about 90% of the dextran loaded in the matrix within 24-48 hours, wherein the first layer comprises pores that have a pore size from about 250 to about 1000 microns and the second layer comprises pores that have a pore size from about 0.05 to about 200 microns.