Aza-bicyloalkyl ethers and their use as alpha7-nachr agonists

摘要

The present invention relates to 1-aza-bicycloalkyl derivatives of formula I,;
wherein X is CH2 or a single bond; Y is a group of formula
;
and wherein R has the meanings as defined in the specification, which compounds are alpha 7 nicotinic acetylcholine receptor (nAChR) agonists; to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.

主权项

1. An aza-bicycloalkyl derivative of formula Iwherein
X is CH2 or a single bond; Y isand
R is
phenyl which is unsubstituted or mono-, di- or trisubstituted by halogen, cyano, methylenedioxy,
C1-C4alkyl, which is unsubstituted or mono-, di- or trisubstituted by halogen, orC1-C4alkoxy, which is unsubstituted or mono-, di- or trisubstituted by halogen,in free base or acid addition salt form.