Process for sodium salt of (2S, 5R)-2-carboxamido-7-oxo-6-sulfooxy -1,6-diaza-bicyclo[3.2.1]octane

摘要

A process for preparation of a sodium salt of (2S,5R)-2-carboxamido-7-oxo-6-sulfooxy-1,6-diaza-bicyclo[3.2.1]octane is disclosed which is comprising the amidation of a compound of Formula (II) to obtain a compound of Formula (III).;

主权项

1. A process for preparation of a compound of Formula (I), comprising: (a) reacting a compound of Formula (II) with 1-hydroxybenzotriazole-ammonia complex in the presence of water as a solvent to obtain a compound of Formula (III); (b) hydrogenolysis of the compound of Formula (III) to obtain a compound of Formula (IV); (c) sulfonating the compound of Formula (IV) to obtain a compound of Formula (V); and (d) converting the compound of Formula (V) into the compound of Formula (I).