Aminoquinoline derivatives and uses thereof

摘要

Described herein are aminoquinoline and aminoacridine based hybrids, pharmaceutical compositions and medicaments that include such aminoquinoline and aminoacridine based hybrids, and methods of using such compounds for diagnosing and/or treating infections, neurodegerative diseases or disorders, inflammation, inflammation associated diseases and disorders, and/or diseases or disorders that are treatable with dopamine agonists such as the restless leg syndrome.

主权项

1. A compound selected from the group consisting of Formula (I)-Formula (X):
Formula (I): wherein:X, Y, and Z are independently CR18, N, O, or S, provided that two of X, Y, and Z are N;one of Z1 and Z2 is N and the other is CR14;R and R10-R18 are independently H, linear or branched alkyl, linear or branched alkenyl, linear or branched alkynyl, cyclyl, heterocyclyl, aryl, heteroaryl, halogen, trifluoromethyl, alkoxy, nitro, cyano, carbonyl, hydroxyl, phenoxy, amino, alkylamino, thiol, or alkylthio, each of which can be optionally substituted; andL is a linker Formula (II): wherein:X and Y are independently CR18, N, O, or S;A and B are independently CR18, N, O, or S;one of Z1 and Z2 is N and the other is CR14;R and R10-R18 are independently H, linear or branched alkyl, linear or branched alkenyl, linear or branched alkynyl, cyclyl, heterocyclyl, aryl, heteroaryl, halogen, trifluoromethyl, alkoxy, nitro, cyano, carbonyl, hydroxyl, phenoxy, amino, alkylamino, thiol, or alkylthio, each of which can be optionally substituted;----- forms a cyclyl, heterocyclyl, aryl, or heteroaryl, each of which can be optionally substituted; andL is a linker; Formula (III): wherein:A and B are independently CR18 or N;one of Z1 and Z2 is N and the other is CR14;R and R10-R18 are independently H, linear or branched alkyl, linear or branched alkenyl, linear or branched alkynyl, cyclyl, heterocyclyl, aryl, heteroaryl, halogen, trifluoromethyl, alkoxy, nitro, cyano, carbonyl, hydroxyl, phenoxy, amino, alkylamino, thiol, or alkylthio, each of which can be optionally substituted; andL is a linker; Formula (IV): wherein:X and Z are independently CR18, N, O, or S;one of Z1 and Z2 is N and the other is CR14;R and R11-R18 are independently H, linear or branched alkyl, linear or branched alkenyl, linear or branched alkynyl, cyclyl, heterocyclyl, aryl, heteroaryl, halogen, trifluoromethyl, alkoxy, nitro, cyano, carbonyl, hydroxyl, phenoxy, amino, alkylamino, thiol, or alkylthio, each of which can be optionally substituted;----- forms a cyclyl, heterocyclyl, aryl, or heteroaryl, each of which can be optionally substituted; andL is a linker; Formula (V): wherein:X, Y, and Z are independently CR18, N, O, or S, provided that X and Y are N or Y and Z are N;one of Z1 and Z2 is N and the other is CR14;R and R11-R18 are independently H, linear or branched alkyl, linear or branched alkenyl, linear or branched alkynyl, cyclyl, heterocyclyl, aryl, heteroaryl, halogen, trifluoromethyl, alkoxy, nitro, cyano, carbonyl, hydroxyl, phenoxy, amino, alkylamino, thiol, or alkylthio, each of which can be optionally substituted; andR10 is linear or branched alkyl, linear or branched alkenyl, linear or branched alkynyl, cyclyl, heterocyclyl, aryl, heteroaryl, halogen, trifluoromethyl, alkoxy, nitro, cyano, carbonyl, hydroxyl, phenoxy, amino, alkylamino, thiol, or alkylthio, each of which can be optionally substituted; Formula (VI): wherein:X, Y, and Z are independently CR18, N, O, or S;R10, R11 and R21-R28 are independently H, linear or branched alkyl, linear or branched alkenyl, linear or branched alkynyl, cyclyl, heterocyclyl, aryl, heteroaryl, halogen, trifluoromethyl, alkoxy, nitro, cyano, carbonyl, hydroxyl, phenoxy, amino, alkylamino, thiol, or alkylthio, each of which can be optionally substituted;andL is a linker; Formula (VII): wherein:X, Y, and Z are independently CR18, N, O, or S;one of Z1 and Z2 is N and the other is CR14; andR and R10-R22 are independently H, linear or branched alkyl, linear or branched alkenyl, linear or branched alkynyl, cyclyl, heterocyclyl, aryl, heteroaryl, halogen, trifluoromethyl, alkoxy, nitro, cyano, carbonyl, hydroxyl, phenoxy, amino, alkylamino, thiol, or alkylthio, each of which can be optionally substituted; Formula (VIII): wherein:X, Y, and Z are independently CR18, N, O, or S;one of Z1 and Z2 is N and the other is CR14; andR and R10-R21 are independently H, linear or branched alkyl, linear or branched alkenyl, linear or branched alkynyl, cyclyl, heterocyclyl, aryl, heteroaryl, halogen, trifluoromethyl, alkoxy, nitro, cyano, carbonyl, hydroxyl, phenoxy, amino, alkylamino, thiol, or alkylthio, each of which can be optionally substituted; Formula (IX): wherein:X, Y, and Z are independently CR18, N, O, or S;one of Z1 and Z2 is N and the other is CR14; andR and R10-R22 are independently H, linear or branched alkyl, linear or branched alkenyl, linear or branched alkynyl, cyclyl, heterocyclyl, aryl, heteroaryl, halogen, trifluoromethyl, alkoxy, nitro, cyano, carbonyl, hydroxyl, phenoxy, amino, alkylamino, thiol, or alkylthio, each of which can be optionally substituted; Formula (X): wherein:R is hydrogen, CH3, Cl, CF3 or CN;R1 is cyclic or acrylic amine; andL is an optionally substituted C2-C30 alkyl, optionally substituted aromatic ring, optionally substituted heteroaryl ring, saturated cyclic ring; amino acid, or peptide;and any pharmaceutically acceptable salt, hydrate, solvate, ester, stereoisomer mixture, or enantiomer thereof.