Cell display of antibody libraries

摘要

The present invention relates to a viral vector encoding for a library of antibodies or antibody fragments that are displayed on the cell membrane when expressed in a cell. The present invention provides cells comprising the viral vector nucleic acids and methods of screening the libraries for antibodies or antibody fragments with desired characteristics.

主权项

1. An isolated antibody comprising a human IgG1 Fc region having a reduced affinity for an effector molecule wherein said reduced affinity results from a one amino acid insertion in the Fc region wherein the amino acid insertion is between amino acid residues at positions selected from the group consisting of: (a) 230 and 231, (b) 238 and 239, (c) 239 and 240, and (d) 240 and 241, wherein the numbering is according to EU index as set forth in Kabat.