| 发明名称 | Compositions and methods related to protein A (SpA) variants | ||
| 摘要 | Disclosed are methods and compositions for treating or preventing a Staphylococcus bacterial infection using a non-toxigenic Protein A (SpA) variant. | ||
| 申请公布号 | US9567379(B2) | 申请公布日期 | 2017.02.14 |
| 申请号 | US201013260878 | 申请日期 | 2010.04.05 |
| 申请人 | The University of Chicago | 发明人 | Schneewind Olaf;Cheng Alice;Missiakas Dominique M.;Kim Hwan Keun |
| 分类号 | A61K39/00;A61K39/02;A61K39/09;A61K39/085;C07K14/31 | 主分类号 | A61K39/00 |
| 代理机构 | Norton Rose Fulbright US LLP | 代理人 | Norton Rose Fulbright US LLP |
| 主权项 | 1. An isolated polypeptide comprising a Staphylococcal Protein A (SpA) variant domain D segment comprising amino acid substitutions at amino acids corresponding to positions 9, 10, 36 and 37 of SEQ ID NO: 2, wherein the substitutions at amino acids corresponding to positions 9 and 10 are with a lysine residue and the substitutions at amino acids corresponding to positions 36 and 37 are with an alanine residue, and wherein the amino acid sequence is at least 80% identical to SEQ ID NO:2. | ||
| 地址 | Chicago IL US | ||