Methods of identifying a subject as having heart failure

摘要

Measurement of circulating ST2 and/or IL-33 concentrations is useful for the prognostic evaluation of subjects, in particular for the prediction of adverse clinical outcomes, e.g., mortality, and the detection of severe disease.

主权项

1. A method of identifying, a subject having undiagnosed chest pain or undiagnosed chest discomfort as having heart failure, the method comprising:
(a) selecting a subject having undiagnosed chest pain or undiagnosed chest discomfort; (b) performing an immunoassay to determine a level of soluble ST2 in a biological sample from the selected subject; (c) performing an immunoassay to determine a level of one or more adjunct biomarkers selected from the group consisting of: N-terminal (NT)-pro-brain natriuretic peptide (BNP), BNP, NT-pro-atrial natriuretic peptide (ANP), proANP, and ANP in a biological sample from the selected subject; (d) comparing the level of soluble ST2 in the selected subject to a reference level of soluble ST2; (e) comparing the level of the one or more adjunct biomarkers in the selected subject to a reference level of the one or more adjunct biomarkers; and (f) identifying a selected subject having an elevation in the level of soluble ST2 compared to the reference level of soluble ST2 and an elevation in the level of the one or more adjunct biomarkers compared to the reference level of the one or more adjunct biomarkers as having heart failure by performing echocardiography.