| 发明名称 | Method of synthesising sulforaphane | ||
| 摘要 | The present invention relates to a method of synthesizing sulforaphane by reacting a compound of formula (A) with an oxidizing agent in an aqueous solvent and in the presence of a catalyst. The invention further provides a method of synthesizing a stabilized complex of sulforaphane and cyclodextrin by mixing the sulforaphane prepared by the methodology defined herein with cyclodextrin in an aqueous solvent.; | ||
| 申请公布号 | US9567405(B2) | 申请公布日期 | 2017.02.14 |
| 申请号 | US201314404773 | 申请日期 | 2013.05.31 |
| 申请人 | PharmAgra Labs, Inc. | 发明人 | Damireddi Sahadeva Reddy;Akue Kpakpo Ambroise;Nelson Jared K.;Frisbee Albert Roger;Newsome Peter Wyatt |
| 分类号 | C07C315/02;C08B37/16;A61K47/48;A61K31/26;A61K31/724;C07C331/20;C08L5/16;B82Y5/00 | 主分类号 | C07C315/02 |
| 代理机构 | Burns & Levinson LLP | 代理人 | Burns & Levinson LLP ;Foley Shawn P. |
| 主权项 | 1. A process for the preparation of a complex of sulforaphane and cyclodextrin, the process comprising: (i) reacting, in an aqueous solvent, a compound of formula A: with an oxidizing agent and in the presence of a catalyst to form sulforaphane; and (ii) mixing the sulforaphane from step (i) with cyclodextrin in an aqueous solvent to form a precipitate of the sulforaphane-cyclodextrin complex, wherein the oxidizing agent is hydrogen peroxide or a water soluble or miscible organic per-acid, or a mixture thereof. | ||
| 地址 | Brevard NC US | ||