| 发明名称 | Compounds including Cox inhibitor moiety and enhanced delivery of active drugs using same | ||
| 摘要 | The presently-disclosed subject matter includes compounds including a cyclooxygenase enzyme inhibitor moiety and a moiety derived from a drug of interest. In some embodiments, the drug of interest is an opioid. In some embodiments, the compound includes a diclofenac moiety and a naltrexone or naltrexol moiety. The compounds allow for enhanced delivery rates across skin. | ||
| 申请公布号 | US9566341(B1) | 申请公布日期 | 2017.02.14 |
| 申请号 | US201213458366 | 申请日期 | 2012.04.27 |
| 申请人 | University of Kentucky Research Foundation | 发明人 | Stinchcomb Audra;Kim Kyung Bo;Pinninti Ragotham Reddy;Ghosh Priyanka;Paudel Kalpana S. |
| 分类号 | A61K47/48;A61K9/70;A61K9/00 | 主分类号 | A61K47/48 |
| 代理机构 | Stites & Harbison PLLC | 代理人 | Stites & Harbison PLLC ;Decker Mandy Wilson |
| 主权项 | 1. A compound having a first moiety derived from an opioid; and a second moiety derived from a cyclooxygenase (COX) enzyme inhibitor; wherein said first moiety is linked to said second moiety to form a single chemical entity; wherein the compound has a structure selected from the group consisting of:wherein n is 1, 2, 3, or 4, and | ||
| 地址 | Lexington KY US | ||