Multimode systems and methods for detecting a sample

摘要

A multimode detection system for detecting one or more samples is provided. The detection system comprises an electromagnetic radiation source, a reference arm, and a sample arm comprising a sensing substrate having a plurality of sample fields, wherein the sample fields are configured to receive the one or more samples. The system further comprises a phase difference generator configured to introduce pathlength differences in the reference arm, sample arm, or both, a spatial light modulator operatively coupled to the reference arm, sample arm, or both, wherein the spatial light modulator is configured to modulate incident radiation, resultant radiation, or both in the reference arm, sample arm, or both, and an imaging spectrometer configured to discriminate between two or more spatially separated sample en two or more spatially separated sample fields.

主权项

1. A multimode detection system for detecting one or more samples, comprising:
an electromagnetic radiation source; a reference arm; a sample arm comprising a sensing substrate having a plurality of sample fields, wherein the sample fields are configured to receive the one or more samples; a phase difference generator configured to introduce one or more pathlength differences in the reference arm, the sample arm, or both; a spatial light modulator disposed in an optical path of the reference arm, the sample arm, or both, wherein the spatial light modulator is configured to spatially modulate incident radiation, resultant radiation, co-propagating radiation, or combinations thereof, wherein the spatial light modulator is configured to select a region of interest in a spatial direction, and wherein the spatial light modulator comprises a variable area light valve; and an imaging spectrometer configured to discriminate between two or more spatially separated sample fields, wherein the imaging spectrometer includes a detector and a grating, wherein the grating comprises a ruling, wherein the ruling is changed to zoom to a given wavelength range generating multiple optical modes, and wherein an area of the variable area light valve that allows light from the sensing substrate to reach the imaging spectrometer is adjusted to modulate an amount of co-propagating radiation that reaches the imaging spectrometer.