发明名称 |
Methods and formulations for treating scars and β-catenin-mediated disorders |
摘要 |
A topical drug composition for treating a β-catenin-mediated disorder in a mammal is provided comprising a Nefopam compound selected from Nefopam, or a functionally equivalent analog, prodrug, salt or solvate thereof. |
申请公布号 |
US9566263(B2) |
申请公布日期 |
2017.02.14 |
申请号 |
US201414577329 |
申请日期 |
2014.12.19 |
申请人 |
Hospital for Sick Children |
发明人 |
Alman Benjamin A.;Poon Raymond;Hong Helen;Gauzer Gene A. |
分类号 |
A61K31/395;A61K31/191;A61K9/00;A61K9/06;A61K47/10 |
主分类号 |
A61K31/395 |
代理机构 |
|
代理人 |
|
主权项 |
1. A topical formulation of Nefopam comprising: 10 mg/g Nefopam HCl or a functionally equivalent salt thereof; 30 mg/g diethylene glycol monoethyl ether; 40 mg/g cetyl alcohol, 30 mg/g stearyl alcohol, 40 mg/g polysorbate 60, 0.5 mg/g propylparaben, 22.5 mg/g isopropyl myristate, purified water, 1 mg/g methylparaben, 0.02 mg/g EDTA, sodium hydroxide; and 5 mg/g calcium gluconate. |
地址 |
Toronto, Ontario CA |