| 发明名称 | Compositions comprising ornithine and phenylacetate or phenylbutyrate for treating hepatic encephalopathy | ||
| 摘要 | The present invention relates to use of ornithine in the manufacture of a medicament for use in combination with at least one of phenylacetate and phenylbutyrate for preventing or treating liver decompensation or hepatic encephalopathy. The invention also relates to use of at least one of phenylacetate and phenylbutyrate in the manufacture of a medicament for use in combination with ornithine for preventing or treating liver decompensation or hepatic encephalopathy. | ||
| 申请公布号 | US9566257(B2) | 申请公布日期 | 2017.02.14 |
| 申请号 | US201213495966 | 申请日期 | 2012.06.13 |
| 申请人 | UCL Business PLC | 发明人 | Jalan Rajiv;Jalan Kamal Nayan |
| 分类号 | A61K31/195;A61K31/192;A61K31/198 | 主分类号 | A61K31/195 |
| 代理机构 | Knobbe Martens Olson & Bear LLP | 代理人 | Knobbe Martens Olson & Bear LLP |
| 主权项 | 1. A pharmaceutical composition comprising ornithine or a physiologically acceptable salt thereof and at least one of phenylacetate or phenylbutyrate or a physiologically acceptable salt thereof, wherein the composition comprises no other amino acid, wherein the ornithine and at least one of phenylacetate or phenylbutyrate are in a weight ratio from 2:1 to 1:2, wherein the composition is formulated for oral administration. | ||
| 地址 | London GB | ||