摘要 |
The invention is directed to triazolopyridazine compounds of Formula I: where R1, R5, R6, R7, R8, and A are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of c-Met, and the use of such compounds to reduce or inhibit kinase activity of c-Met in a cell or a subject, and modulate c-Met expression in a cell or subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to c-Met. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders. |
申请人 |
Janssen Pharmaceutica N.V. |
发明人 |
Lu, Tianbao;ALEXANDER, Richard;CONNORS, Richard, W.;CUMMINGS, Maxwell, D.;GALEMMO, Robert, A.;JOHNSON, Dana, L.;Khalil, Ehab;LEONARD, Kristi, A.;MARKOTAN, Thomas, P.;MARONEY, Anna, C.;TUMAN, Robert, W.;HUFNAGEL, Heather, Rae;TRAVINS, Jeremy, M.;SECHLER, Jan, L. |