发明名称 |
HIGH CONCENTRATION ANTI-TNF ALPHA ANTIBODY LIQUID FORMULATIONS |
摘要 |
The invention provides a liquid aqueous pharmaceutical formulation comprising a human anti-TNFa antibody, or antigen-binding portion thereof, which reduces pain associated with injection in a subject by at least about 50% when compared to injecting an otherwise identical formulation comprising at least one salt and/or at least one buffer. The invention also provides a liquid aqueous pharmaceutical formulation comprising a human anti-TNFa antibody, or antigen-binding portion thereof, having increased bioavailability upon subcutaneous administration into a subject. The formulation may comprise a therapeutic protein, such as a human anti-TNF-alpha antibody, or an antigen-binding portion thereof, or a biosimilar thereof. |
申请公布号 |
HRP20161753(T1) |
申请公布日期 |
2017.02.10 |
申请号 |
HR2016P001753T |
申请日期 |
2016.12.20 |
申请人 |
AbbVie Biotechnology Ltd |
发明人 |
Neu, Michael;Tschoepe, Markus;Weber, Carsten;Redden, Laura;Fraunhofer, Wolfgang;Gastens, Martin;Feick, Alexander;Paulson, Susan K.;Zhu, Tong |
分类号 |
A61K39/395 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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