| 发明名称 |
MITOCHONDRIA-TARGETING PLATINUM(IV) PRODRUG |
| 摘要 |
Pt(IV) compounds include a mitochondria targeting moiety. One example of a Pt(IV) compound having a mitochondria targeting moiety is a Pt(IV) cisplatin-based compound. Upon reduction, the mitochondrial targeting moieties are released resulting in a Pt(II) therapeutic agent. Pt(IV) compounds including a mitochondria targeting moiety can be included in nanoparticles. The compounds or nanoparticles can be used to treat, for example, cancer. |
| 申请公布号 |
US2017037071(A1) |
申请公布日期 |
2017.02.09 |
| 申请号 |
US201515302549 |
申请日期 |
2015.04.08 |
| 申请人 |
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. |
发明人 |
Dhar Shanta;Pathak Rakesh;Marrache Sean |
| 分类号 |
C07F15/00 |
主分类号 |
C07F15/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A compound of comprising:
a prodrug comprising a PT(IV) moiety, and one or more mitochondria targeting moieties conjugated to the to a Pt(IV) moiety of the prodrug, wherein reduction of Pt(IV) of the Pt(IV) moiety to Pt(II) releases the one or more mitochondria-targeting moieties from the compound and results in a Pt(II) therapeutic agent. |
| 地址 |
Athens GA US |
