Compositions and Methods for Inhibiting Pro-Inflammatory Cytokine Gene Expression

摘要

θ-defensins, non-human macrocyclic peptides, have been found to reduce expression of genes encoding for various pro-inflammatory peptides (such as cytokines and chemokines) in a highly selective manner. Methods for treating inflammatory conditions utilizing a θ-defensin and/or a θ-defensin analog, methods for modifying (e.g. down regulating) gene expression for pro-inflammatory peptides in a subject in need thereof using a θ-defensin and/or a θ-defensin analog, methods for selectively modifying expression of such genes and/or reducing pro-inflammatory peptides in a subject without inducing or worsening immunosuppression using a θ-defensin and/or a θ-defensin analog are discussed, as are compositions that include a θ-defensin and/or a θ-defensin analog in an amount and/or form suitable for use in such methods.

主权项

1. A method for modulation of multiple pro-inflammatory peptides in a human or nonhuman mammal, comprising administering a θ-defensin or θ-defensin analog to a subject in need thereof, in an amount effective to modulate a plurality of pro-inflammatory peptides by suppressing gene expression of the pro-inflammatory peptides.