IMMEDIATE RELEASE FILM COATINGS CONTAINING MEDIUM CHAIN GLYCERIDES AND SUBSTRATES COATED THEREWITH

摘要

The present invention is directed to immediate release film coating compositions for use on oral dosage forms such as compressed tablets and other orally-ingestible substrates which contain medium chain glycerides as detackifiers. The film coating compositions can be applied either directly to a substrate or after the substrate has been coated with a subcoat. In preferred aspects, the polymer is polyvinyl alcohol and the medium chain glycerides are mixtures of caprylic (8 carbon chain) and capric (10 carbon chain) mono- and diesters of glycerin. Aqueous suspensions comprising the inventive film coating compositions, methods of applying the coatings to substrates and the coated substrates themselves are also disclosed.

主权项

1. A method of making an aqueous film coating dispersion comprising dispersing an immediate release film coating composition comprising:
a) a polymer selected from the group consisting of hypromellose (hydroxypropyl methylcellulose), hydroxypropyl cellulose, sodium carboxymethyl cellulose, polyvinyl alcohol, copolymers based on polyvinyl alcohol, and mixtures thereof; b) a detackifier selected from the group consisting of medium chain glycerides containing less than or equal to about 10% by weight of triesters of glycerin; and c) a member of the group consisting of glidants, pigments, surfactants and mixtures thereof, in water at ambient temperature.