METHODS FOR DIAGNOSING & TREATING COPPER-DEPENDENT DISEASES

摘要

Described are methods and materials for diagnosing a subject's predisposition for cardiovascular disease by detecting a copper deficiency genetic marker, as well as methods of alleviating Cu transport impairment. Specifically, the Cu deficiency genetic marker may be within the gene encoding a transmembrane Cu transporter protein (Ctri) or its regulatory sequences.

主权项

1. A method for determining a subject's predisposition for a Cu-dependent disease, comprising:
(a) providing a nucleic acid-containing sample obtained from a subject; and (b) determining whether a Cu-dependent marker is present in the sample; and wherein the marker is rs2233915, wherein the presence of the marker indicates that the subject has a predisposition for a Cu-dependent disease.