SERUM FRACTION OF PLATELET-RICH FIBRIN

摘要

The invention provides for a method of preparing an isolated serum fraction of platelet rich fibrin (PRF), comprising the steps of
a. providing platelet rich plasma (PRP) without the addition of an anticoagulant;b. clotting the PRP to obtain a coagel of PRF; andc. separating the coagel to isolate the serum fraction which comprises an activated platelet releasate;and further provides for the isolated serum fraction obtained by such method, and its medical use.

主权项

1. A pharmaceutical preparation comprising a blood-derived serum product which is an isolated serum fraction of platelet rich fibrin (PRF) said a blood-derived serum product being contained in an application device for administration of the serum fraction to an individual and being obtained by a method comprising the steps of
a. separating and removing the red blood cell fraction from a venous blood sample without the addition of an anticoagulant to provide a plasma having a platelet concentration above baseline; b. clotting said plasma to obtain a coagel of PRF spontaneously by centrifugation carried out at 1000 to 5000 g; c. pressing or squeezing the coagel to separate a serum fraction which comprises an activated platelet releasate from the coagel, thereby obtaining an isolated serum fraction containing the fluid fraction of PRF; and d. providing the serum fraction in a pharmaceutical preparation which is contained in an application device for administration of the serum fraction to an individual, said serum fraction comprising a platelet releasate from activated platelets.