TANGENTIAL FLOW FILTER SYSTEM FOR THE FILTRATION OF MATERIALS FROM BIOLOGIC FLUIDS

摘要

Systems and methods for filtering materials from biologic fluids are discussed. Embodiments may be used to filter cerebrospinal fluid (CSF) from a human or animal subject. The method may include the steps of withdrawing fluid comprising CSF, filtering the volume into permeate and retentate by passing the fluid through a tangential flow filter, and returning the permeate to the subject. During operation of the system, various parameters may be modified, such as flow rate.

主权项

1. A method for filtering materials from cerebrospinal fluid (CSF) of a human or animal subject, the method comprising the steps of:
withdrawing a volume of fluid comprising CSF from a CSF-containing space of the subject at a first flow rate using a filtration system, the filtration system operating according to a set of parameters; filtering the volume of fluid into permeate and retentate using a tangential flow filter of the filtration system; measuring a characteristic of the fluid using a sensor of the filtration system; returning the permeate to the lumen of the subject at a second flow rate; and updating a parameter of the set of operation parameters based on the measured characteristic responsive to determining the measured characteristic passes a predetermined threshold.