MULTI-LAYERED ORALLY DISINTEGRATING TABLET AND THE MANUFACTURE THEREOF

摘要

The present invention features a tablet containing a first layer and a second layer, wherein: (i) the first layer includes a pharmaceutically active agent and the composition of the first layer is different from the composition of the second layer; (ii) the tablet has a density less than about 0.8 g/cc; and (iii) the tablet disintegrates in the mouth when placed on the tongue in less than about 30 seconds.

主权项

1. A process for making a tablet comprising a first layer and a second layer, said method comprising:
adding a first powder blend to a die platen, wherein said first powder blend comprises a pharmaceutically active agent and a binder; adding a second powder blend to said die platen, wherein said second powder blend comprises a binder and wherein the composition of said second powder blend is different from the composition of said first powder blend; tamping said first powder blend and second powder blend in said die platen to form a tamped tablet shape; and applying energy to said tamped tablet shape for a sufficient period of time to activate said binders within said tablet shape to fuse said tablet shape into said tablet such that said tablet has a density less than about 0.8 g/cc and said tablet disintegrates in the mouth when placed on the tongue in less than about 30 seconds.