Mineralization and Biological Modification of Biomaterial Surfaces

摘要

Disclosed are advantageous methods for patterning and/or mineralizing biomaterial surfaces. The techniques described are particularly useful for generating three-dimensional or contoured bioimplant materials with patterned surfaces or patterned, mineralized surfaces. Also provided are various methods of using the mineralized and/or patterned biomaterials in tissue engineering, such as bone tissue engineering, providing more control over ongoing biological processes, such as mineralization, growth factor release, cellular attachment and tissue growth.

主权项

1. A method for mineralizing a biomaterial surface, comprising:
functionalizing at least a first inner pore surface of a biomaterial, wherein the biomaterial comprises at least a first porous, biodegradable polymer portion having an interconnected pore structure; and contacting the at least first inner pore surface of the biomaterial with an amount of a mineral-containing solution effective to form a mineralized biomaterial, wherein the mineralized biomaterial comprises a mineral coating at the functionalized at least first inner pore surface of the biomaterial.