FLUORESCENT CONJUGATES

摘要

The invention provides a conjugate with fluorochrome moiety F coupled to a targeting moiety T. Moiety F is described by formula (I), and the targeting moiety T is characterised in that it has affinity to a tumour marker, such as an antibody or antibody fragment. The conjugate may be used for tumour diagnostics including photodetection of tumour nodules during resection surgery.

主权项

1. A fluorescent conjugate comprising a fluorochrome moiety F coupled to a targeting moiety T, wherein moiety F has the formula (I): wherein Y is independently for each occurrence selected from SO3H, SO3—, and SO3M, wherein M is a monovalent cation; x, z and y are independently selected from an integer of 1 to 8; and wherein moiety T has affinity to a tumour marker.