| 发明名称 |
METHODS OF TREATING EARLY BREAST CANCER WITH TRASTUZUMAB-MCC-DM1 AND PERTUZUMAB |
| 摘要 |
Methods of treating patients having HER2-positive, operable, locally advanced or inflammatory breast cancer with the antibody-drug conjugate Trastuzumab-MCC-DM1 and Pertuzumab are provided. |
| 申请公布号 |
US2017035907(A1) |
申请公布日期 |
2017.02.09 |
| 申请号 |
US201615331700 |
申请日期 |
2016.10.21 |
| 申请人 |
Genentech, Inc. |
发明人 |
Green Marjorie C.;Guardino Alice Elizabeth |
| 分类号 |
A61K47/48;C07K16/32 |
主分类号 |
A61K47/48 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for the treatment of breast cancer, comprising
(i) subjecting a patient with HER2-positive, operable, locally advanced or inflammatory breast cancer to neoadjuvant treatment with a combination of T-DM1 and pertuzumab, in the absence of chemotherapy, (ii) removing said breast cancer by definitive surgery; and (iii) subjecting said patient to adjuvant treatment with a combination of T-DM1 and Pertuzumab, in the absence of chemotherapy. |
| 地址 |
South San Francisco CA US |
